Growth disturbance associated with chronic renal insufficiency

Indication for Somatropin

Population group: Suitable for both men and women, only minors (0 - 18 years old)
Therapeutic intent: Curative procedure

In chronic renal insufficiency, renal function should be below 50 percent of normal before institution of therapy. To verify growth disturbance, growth should be followed for a year preceding institution of therapy. During this period, conservative treatment for renal insufficiency (which includes control of acidosis, hyperparathyroidism and nutritional status) should have been established and should be maintained during treatment. The treatment should be discontinued at renal transplantation.

To date, no data on final height in patients with chronic renal insufficiency treated with somatropin are available.

For this indication, competent medicine agencies globally authorize below treatments:

45-50 ug/kg once daily

For: Newborns Infants Children Adolescents

Route of admnistration

Subcutaneous

Defined daily dose

45 - 50 ug per kg of body weight

Dosage regimen

From 45 To 50 ug per kg of body weight once every day

Detailed description

A dose of 0.045-0.050 mg/kg body weight per day is recommended. Higher doses can be needed if growth velocity is too low. A dose correction can be needed after six months of treatment.

Dosage considerations

The injection should be given subcutaneously and the site varied to prevent lipoatrophy.

1.4 mg/m² once daily

For: Newborns Infants Children Adolescents

Route of admnistration

Subcutaneous

Defined daily dose

1.4 - 1.4 mg per m² of body surface area (BSA)

Dosage regimen

From 1.4 To 1.4 mg per m² of body surface area (BSA) once every day

Detailed description

A dose of 1.4 mg/m² body surface area per day is recommended. Higher doses can be needed if growth velocity is too low. A dose correction can be needed after six months of treatment.

Dosage considerations

The injection should be given subcutaneously and the site varied to prevent lipoatrophy.

Active ingredient

Somatropin is a potent metabolic hormone of importance for the metabolism of lipids, carbohydrates and proteins. In children with inadequate endogenous growth hormone, somatropin stimulates linear growth and increases growth rate. In adults, as well as in children, somatropin maintains a normal body composition by increasing nitrogen retention and stimulation of skeletal muscle growth, and by mobilization of body fat.

Read more about Somatropin

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