Active Ingredient: Somatropin
In chronic renal insufficiency, renal function should be below 50 percent of normal before institution of therapy. To verify growth disturbance, growth should be followed for a year preceding institution of therapy. During this period, conservative treatment for renal insufficiency (which includes control of acidosis, hyperparathyroidism and nutritional status) should have been established and should be maintained during treatment.
The treatment should be discontinued at renal transplantation.
To date, no data on final height in patients with chronic renal insufficiency treated with somatropin are available.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A
Subcutaneous, between 0.045 milligrams somatropin per kilogram of body weight and 0.05 milligrams somatropin per kilogram of body weight, once daily.
Regimen B
Subcutaneous, 1.4 milligrams somatropin per square meter of body surface, once daily.
The posology and administration schedule should be individualised.
A dose of 0.045-0.050 mg/kg body weight per day (1.4 mg/m² body surface area per day) is recommended. Higher doses may be needed if growth velocity is too low. A dose correction can be needed after six months of treatment.
The injection should be given subcutaneously and the site varied to prevent lipoatrophy.
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