Post-partum haemorrhage

Active Ingredient: Carboprost

Indication for Carboprost

Population group: women, only adults (18 - 65 years old)

Treatment of post-partum haemorrhage due to uterine atony and refractory to conventional methods of treatment with oxytocic agents and ergometrine used either alone or in combination.

Conventional therapy should usually consist of 0.5-1 mg ergometrine with up to 50 units of oxytocin infused intravenously over periods of time from 20 minutes to 12 hours. The dosage and duration of administration should reflect the seriousness of the clinical situation.

For this indication, competent medicine agencies globally authorize below treatments:

250-2000 ug

Route of admnistration

Intramuscular

Defined daily dose

250 - 2,000 ug

Dosage regimen

From 250 To 2,000 ug once every day

Loading dose

250 ug

Detailed description

An initial dose of 250 micrograms of carboprost should be administered as a deep intramuscular injection.

If necessary, further doses of 250 micrograms may be administered at intervals of approximately 1.5 hours. In severe cases the interval between doses may be reduced at the discretion of the attending physician, but it should not be less than 15 minutes. The total dose of carboprost should not exceed 2 mg.

Active ingredient

Carboprost

Carboprost is a synthetic 15-methyl analogue of dinoprost (prostaglandin F2 alpha). Administered intramuscularly carboprost stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. It is indicated for aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and for the treatment of postpartum hemorrhage due to uterine atony, which has not responded to conventional methods of management. The most frequent adverse reactions observed are related to its contractile effect on smooth muscle: vomiting, diarrhea, nausea, fever and flushing. Carboprost may augment the activity of other oxytocic agents. Concomitant use with other oxytocic agents is not recommended.

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