Cranial and spinal magnetic resonance imaging (MRI)

Active Ingredient: Gadobutrol

Indication for Gadobutrol

Population group: only minors (0 - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.1 mmol/kg


Dosage regimens

Intravenous, 0.1 micromoles gadobutrol per kilogram of body weight, one dose.

Detailed description

The recommended dose for adults is 0.1 mmol per kilogram body weight (mmol/kg BW). This is equivalent to 0.1 ml/kg BW of the 1.0 M solution.

If a strong clinical suspicion of a lesion persists despite an unremarkable MRI or when more accurate information might influence therapy of the patient, a further injection of up to 0.2 ml/kg BW within 30 minutes of the first injection may be performed.

0.1 mmol/kg


Route of admnistration

Defined daily dose

Dosage regimen

$d time(s) per day every $document.frequencyDenominator day(s)

Detailed description

Neonates up to 4 weeks of age and infants up to 1 year of age

Due to immature renal function in neonates up to 4 weeks of age and infants up to 1 year of age, gadobutrol should only be used in these patients after careful consideration at a dose not exceeding 0.1 mmol/kg body weight. More than one dose should not be used during a scan. Because of the lack of information on repeated administration, gadobutrol injections should not be repeated unless the interval between injections is at least 7 days.

Active ingredient


Gadobutrol is a gadolinium-based, hydrophilic, macrocyclic, electrically neutral contrast agent used in contrast-enhanced MRI (CE-MRI).

Read more about Gadobutrol

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