Osteoarthritis, rheumatoid arthritis

Active Ingredient: Nabumetone

Indication for Nabumetone

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For use in osteoarthritis and rheumatoid arthritis requiring anti-inflammatory and analgesic treatment.

For this indication, competent medicine agencies globally authorize below treatments:

1 g once daily

For:

Dosage regimens

Oral, 1 grams nabumetone, once daily at the end of the day.

Detailed description

The recommended daily dose is 1 g taken as a single dose at bedtime.

For severe or persistent symptoms, or during acute exacerbations, an additional dose 500 mg – 1 g may be given as a morning dose.

Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms.

Elderly

In common with many drugs, blood levels may be higher in elderly patients. The recommended daily dose of 1 g should not be exceeded in this age group and in some cases 500 mg may give satisfactory relief.

The elderly are at increased risk of the serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest dose should be used and for the shortest duration. The patient should be monitored regularly for gastrointestinal bleeding during NSAID therapy.

Dosage considerations

Taken at bedtime.

Should be taken preferably with or after food.

Active ingredient

Nabumetone

Nabumetone is a non acidic non steroidal anti-inflammatory agent with weak prostaglandin synthesis properties. Nabumetone undergoes rapid and extensive metabolism in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), the principal active metabolite which is a potent inhibitor of prostaglandin synthesis.

Read more about Nabumetone

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