Unstable angina

Active Ingredient: Abciximab

Indication for Abciximab

Population group: only adults (18 years old or older)

Abciximab is indicated as an adjunct to heparin and acetylsalicylic acid for the short-term (1-month) reduction of the risk of myocardial infarction, in patients with unstable angina, not responding to full conventional therapy who have been scheduled for percutaneous coronary intervention.

For this indication, competent medicine agencies globally authorize below treatments:

0.25mg/kg intravenous bolus

Route of admnistration

Intravenous

Defined daily dose

0.25 mg per kg of body weight

Dosage regimen

0.25 mg per kg of body weight once every day

Detailed description

The recommended dose of Abciximab is a 0.25mg/kg intravenous bolus immediately followed by a 0.125 microgram/kg/min (to a maximum of 10 microgram/min) continuous intravenous infusion.

For the stabilisation of unstable angina patients, the bolus dose followed by the infusion should be started up to 24 hours prior to the possible intervention and concluded 12 hours after the intervention.

For the prevention of ischaemic cardiac complications in patients undergoing percutaneous coronary intervention, and who are not currently receiving an abciximab infusion, the bolus should be administered 10 to 60 minutes prior to the intervention followed by the infusion for 12 hours.

Active ingredient

Abciximab

Abciximab is the Fab fragment of the chimeric monoclonal antibody 7E3. It is directed against the glycoprotein (GP) IIb/IIIa (αIIbβ3) receptor located on the surface of human platelets. Abciximab inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules to GPIIb/IIIa receptor sites on activated platelets.

Read more about Abciximab

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