Hypertensive crisis

Active Ingredient: Urapidil

Indication for Urapidil

Population group: only adults (18 years old or older)

Hypertensive emergencies (e.g. a critical rise in blood pressure).

For this indication, competent medicine agencies globally authorize below treatments:

10-50 mg

Route of admnistration

Intravenous

Defined daily dose

10 - 50 mg

Dosage regimen

From 10 To 50 mg once every day

Detailed description

Intravenous injection: 10-50 mg urapidil is slowly administered by intravenous injection – while constantly monitoring the blood pressure. A fall in blood pressure can be expected within 5 min. of administering the injection.

The injection of 10-50 mg urapidil can be repeated depending how the blood pressure reacts.

Intravenous infusion or syringe pump are used to maintain the level of blood pressure achieved by the injection.

The maximum quantity compatible is 4 mg urapidil per ml of solution for infusion.

Speed of administration: The infusion rate is determined from the individual blood pressure situation. Initial recommended maximum infusion rate: 2 mg/min.

Maintenance dose: On average 9 mg/h, referring to 250 mg urapidil added to 500 ml solution for infusion corresponding to 1 mg = 44 drops = 2.2 ml.

Active ingredient

Urapidil

Urapidil is a α1-adrenoceptor antagonist and 5-HT1A receptor agonist and consequently inhibits the vasoconstrictor effect of catecholamines. It interacts with peripheral α1-adrenoceptors and central 5-HT1A receptors to produce vasodilation without sympathetic activation.

Read more about Urapidil

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