Castration-resistant prostate cancer (CRPC)

Active Ingredient: Enzalutamide

Indication for Enzalutamide

Population group: men, only adults (18 years old or older)

Enzalutamide is indicated for:

  • the treatment of adult men with high-risk non-metastatic castration-resistant prostate cancer (CRPC).
  • the treatment of adult men with metastatic CRPC who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated.
  • the treatment of adult men with metastatic CRPC whose disease has progressed on or after docetaxel therapy.

For this indication, competent medicine agencies globally authorize below treatments:

160 mg once daily

Route of admnistration

Oral

Defined daily dose

160 - 160 mg

Dosage regimen

From 160 To 160 mg once every day

Detailed description

The recommended dose is 160 mg enzalutamide as a single oral daily dose.

Medical castration with a luteinising hormone-releasing hormone (LHRH) analogue should be continued during treatment of patients not surgically castrated.

If a patient misses taking Xtandi at the usual time, the prescribed dose should be taken as close as possible to the usual time. If a patient misses a dose for a whole day, treatment should be resumed the following day with the usual daily dose.

If a patient experiences a ≥ Grade 3 toxicity or an intolerable adverse reaction, dosing should be withheld for one week or until symptoms improve to ≤ Grade 2, then resumed at the same or a reduced dose (120 mg or 80 mg) if warranted.

Dosage considerations

It can be taken with or without food.

Active ingredient

Enzalutamide

Enzalutamide is a potent androgen receptor signalling inhibitor that blocks several steps in the androgen receptor signalling pathway. Enzalutamide treatment decreases the growth of prostate cancer cells and can induce cancer cell death and tumour regression.

Read more about Enzalutamide

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