Active Ingredient: Eliglustat
Eliglustat is indicated for the long-term treatment of adult patients with Gaucher disease type 1 (GD1), who are CYP2D6 poor metabolisers (PMs), intermediate metabolisers (IMs) or extensive metabolisers (EMs).
For this indication, competent medicine agencies globally authorize below treatments:
Oral
84 - 168 mg
From 42 To 84 mg 2 time(s) per day every day
The recommended dose is 84 mg eliglustat twice daily in CYP2D6 intermediate metabolisers (IMs) and extensive metabolisers (EMs). The recommended dose is 84 mg eliglustat once daily in CYP2D6 poor metabolisers (PMs).
If a dose is missed, the prescribed dose should be taken at the next scheduled time; the next dose should not be doubled.
Eliglustat should not be used in patients who are CYP2D6 ultra-rapid metabolisers (URMs) or indeterminate metabolisers.
Eliglustat may be taken with or without food. Consumption of grapefruit or its juice should be avoided.
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