Chronic spontaneous urticaria (CSU)

Active Ingredient: Omalizumab

Indication for Omalizumab

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Omalizumab is indicated as add-on therapy for the treatment of chronic spontaneous urticaria in adult and adolescent (12 years and above) patients with inadequate response to H1 antihistamine treatment.

For this indication, competent medicine agencies globally authorize below treatments:

300 mg once every four weeks

Route of admnistration

Subcutaneous

Defined daily dose

300 - 300 mg

Dosage regimen

From 300 To 300 mg once every 28 day(s)

Detailed description

The recommended dose is 300 mg by subcutaneous injection every four weeks.

Prescribers are advised to periodically reassess the need for continued therapy.

Clinical trial experience of long-term treatment beyond 6 months in this indication is limited.

Active ingredient

Omalizumab

Omalizumab is a recombinant DNA-derived humanised monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Omalizumab binds to IgE and prevents binding of IgE to FcεRI (high-affinity IgE receptor) on basophils and mast cells, thereby reducing the amount of free IgE that is available to trigger the allergic cascade. Treatment of atopic subjects with omalizumab resulted in a marked down-regulation of FcεRI receptors on basophils.

Read more about Omalizumab

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