Active Ingredient: Anidulafungin
Treatment of invasive candidiasis in adults and paediatric patients aged 1 month to <18 years.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 200 milligrams anidulafungin, one dose, over the duration of 1 day. Afterwards, intravenous, 100 milligrams anidulafungin, once daily, over the duration of 14 to 35 days.
Specimens for fungal culture should be obtained prior to therapy. Therapy may be initiated before culture results are known and can be adjusted accordingly once they are available.
A single 200 mg loading dose should be administered on Day 1, followed by 100 mg daily thereafter. Duration of treatment should be based on the patient's clinical response.
In general, antifungal therapy should continue for at least 14 days after the last positive culture.
There are insufficient data to support the 100 mg dose for longer than 35 days of treatment.
For:
In case that patient age in months is ≥ 1
Intravenous, 3 milligrams anidulafungin per kilogram of body weight, one dose, over the duration of 1 day. Afterwards, intravenous, 1.5 milligrams anidulafungin per kilogram of body weight, once daily, over the duration of 14 to 35 days.
A single loading dose of 3.0 mg/kg (not to exceed 200 mg) should be administered on Day 1 followed by a daily maintenance dose of 1.5 mg/kg (not to exceed 100 mg) thereafter.
Duration of treatment should be based on the patient's clinical response.
In general, antifungal therapy should continue for at least 14 days after the last positive culture.
The safety and efficacy of anidulafungin have not been established in neonates (<1 month old).
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