Acute hypotension due to loss of vasoconstrictor tone

Active Ingredient: Metaraminol

Indication for Metaraminol

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For the treatment of acute hypotension due to loss of vasoconstrictor tone as may occur during spinal anaesthesia and as an adjunct to accepted remedial procedures.

For this indication, competent medicine agencies globally authorize below treatments:

0.5-100 mg

Route of admnistration


Defined daily dose

0.5 - 100 mg

Dosage regimen

From 0.5 To 100 mg once every day

Detailed description

Direct intravenous injection in grave emergencies: 0.5-5 mg, which may be followed by an infusion of 15–100mg titrated to clinical effect. When vasoactive drug support is no longer indicated, the infusion should be gradually decreased. Abrupt withdrawal can result in acute hypotension.

Active ingredient


Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure, is an adrenergic receptor alpha-1 agonist. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol is also used in the treatment of priapism, in spite of this application was not approved, it appears to be effective.

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