Active Ingredient: Olmesartan medoxomil
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 10 milligrams olmesartan medoxomil, once daily. Afterwards, oral, between 10 milligrams olmesartan medoxomil and 40 milligrams olmesartan medoxomil, once daily. The maximum allowed total dose is 40 milligrams olmesartan medoxomil daily.
The recommended starting dose of olmesartan medoxomil is 10 mg once daily. In patients whose blood pressure is not adequately controlled at this dose, the dose of olmesartan medoxomil may be increased to 20 mg once daily as the optimal dose. If additional blood pressure reduction is required, olmesartan medoxomil dose may be increased to a maximum of 40 mg daily or hydrochlorothiazide therapy may be added.
The antihypertensive effect of olmesartan medoxomil is substantially present within 2 weeks of initiating therapy and is maximal by about 8 weeks after initiating therapy. This should be borne in mind when considering changing the dose regimen for any patient.
No adjustment of dosage is generally required in elderly people. If up-titration to the maximum dose of 40 mg daily is required, blood pressure should be closely monitored.
As with all other angiotensin II antagonists, the blood pressure lowering effect of olmesartan medoxomil is somewhat less in black patients than in non-black patients, possibly because of a higher prevalence of low-renin status in the black hypertensive population.
In order to assist compliance, it is recommended that olmesartan be taken at about the same time each day, with or without food, for example at breakfast time.
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