Severe hypertriglyceridaemia, mixed hyperlipidaemia

Indication for Fenofibrate

Population group: Suitable for both men and women, only adults (18 years old or older)

Fenofibrate is indicated as an adjunct to diet and other non pharmacological treatment (e.g. exercise, weight reduction) for the following:

  • Treatment of severe hypertriglyceridaemia with or without low HDL cholesterol.
  • Mixed hyperlipidaemia when a statin is contraindicated or not tolerated.
  • Mixed hyperlipidaemia in patients at high cardiovascular risk in addition to a statin when triglycerides and HDL cholesterol are not adequately controlled.

For this indication, competent medicine agencies globally authorize below treatments:

200 mg once daily

Route of admnistration

Oral

Defined daily dose

200 - 200 mg

Dosage regimen

From 200 To 200 mg once every day

Detailed description

The recommended initial dose is 200 mg taken daily during a main meal. In elderly patients without renal impairment, the normal adult dose is recommended. Since it is less well absorbed from an empty stomach, fenofibrate should always be taken with food. Dietary restrictions instituted before therapy should be continued.

Response to therapy should be monitored by determination of serum lipid values. Rapid reduction of serum lipid levels usually follows fenofibrate treatment, but treatment should be discontinued if an adequate response has not been achieved within three months.

Dosage considerations

It should be taken daily during a main meal.

Active ingredient

The lipid-lowering properties of fenofibrate have been explained in vivo by activation of Peroxisome Proliferator Activated Receptor ╬▒ (PPAR╬▒). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of Apoprotein C-III.

Read more about Fenofibrate

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