Active Ingredient: Pirtobrutinib
Pirtobrutinib as monotherapy is indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) who have been previously treated with a Bruton’s tyrosine kinase (BTK) inhibitor.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 200 milligrams pirtobrutinib, once daily.
The recommended dose is 200 mg pirtobrutinib once daily (QD).
Pirtobrutinib dosing should be interrupted until recovery to Grade 1 or baseline when the patient experiences the following event:
Asymptomatic lymphocytosis is not regarded as an adverse reaction, and patients experiencing this event should continue taking pirtobrutinib.
In the clinical study, adverse events in a limited number of patients were managed by dose reduction.
Treatment should be continued until disease progression or unacceptable toxicity.
If more than 12 hours have passed after a patient has missed a dose, the patient should be instructed to take the next dose at its scheduled time; an additional dose should not be taken. If vomiting occurs, the patient should not take an additional dose but continue with the next scheduled dose.
It can be taken with or without food. Patients should take the dose at approximately the same time every day.
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