Induction of anaesthesia

Indication for Midazolam

Population group: Suitable for both men and women, only adults (18 years old or older)

As an alternative intravenous agent for the induction of anaesthesia in high risk and elderly patients, especially where cardiovascular stability is of particular importance. Induction is more reliable when heavy opiate premedication has been administered or when midazolam is given with a narcotic analgesic such as fentanyl.

For this indication, competent medicine agencies globally authorize below treatments:

0.2-0.3 mg/kg

Route of admnistration


Defined daily dose

0.2 - 0.3 mg per kg of body weight

Dosage regimen

From 0.2 To 0.3 mg per kg of body weight once every day

Detailed description

The dose should be titrated against the individual response of the patient. Midazolam Injection should be given by slow intravenous injection until there is a loss of eyelid reflex, response to commands and voluntary movements.

In anticipating the required dose of midazolam, both the premedication already given and the age of the patient are important. Young, fit unpremedicated patients may require at least 0.3mg/kg body-weight, whereas patients premedicated with an opiate usually require only 0.2mg/kg body-weight.

Active ingredient

Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of midazolam to form water-soluble salts with acids.

Read more about Midazolam

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