Moderate to severe plaque psoriasis

Active Ingredient: Bimekizumab

Indication for Bimekizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

320 mg at week 0, 4, 8, 12, 16 and every 8 weeks thereafter

Dosage regimens

Subcutaneous, 320 milligrams bimekizumab, once every 4 weeks, 5 doses in total. Afterwards, subcutaneous, 320 milligrams bimekizumab, once every 8 weeks.

Detailed description

The recommended dose for adult patients with plaque psoriasis is 320 mg (given as 2 subcutaneous injections of 160 mg each) at week 0, 4, 8, 12, 16 and every 8 weeks thereafter.

Consideration should be given to discontinuing treatment in patients who have shown no improvement by 16 weeks of treatment.

Overweight patients

For some patients with a body weight ≄120 kg who did not achieve complete skin clearance at week 16, 320 mg every 4 weeks after week 16 may further improve treatment response.

Dosage considerations

Suitable areas for injection include thigh, abdomen and upper arm. Injection sites should be rotated and injections should not be given into psoriasis plaques or areas where the skin is tender, bruised, erythematous, or indurated.

The pre-filled syringe or pre-filled pen must not be shaken.

Active ingredient

Bimekizumab

Bimekizumab is a humanised IgG1/Îș monoclonal antibody that selectively binds with high affinity to IL-17A, IL-17F and IL-17AF cytokines, blocking their interaction with the IL-17RA/IL-17RC receptor complex. Elevated concentrations of IL-17A and IL-17F have been implicated in the pathogenesis of several immune-mediated inflammatory diseases including plaque psoriasis.

Read more about Bimekizumab

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