Mucopolysaccharidosis I

Active Ingredient: Laronidase

Indication for Laronidase

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Aldurazyme is indicated for long-term enzyme replacement therapy in patients with a confirmed diagnosis of mucopolysaccharidosis I (MPS I; α-L-iduronidase deficiency) to treat the non-neurological manifestations of the disease.

For this indication, competent medicine agencies globally authorize below treatments:

100 U/kg once every week

Route of admnistration

Intravenous

Defined daily dose

100 - 100 [iU] per kg of body weight

Dosage regimen

From 100 To 100 [iU] per kg of body weight once every 7 day(s)

Detailed description

The recommended dosage regimen of laronidase is 100 U/kg body weight administered once every week.

Dosage considerations

The initial infusion rate of 2 U/kg/h may be incrementally increased every fifteen minutes, if tolerated, to a maximum of 43 U/kg/h. The total volume of the administration should be delivered in approximately 3-4 hours.

Active ingredient

Laronidase

Laronidase is a recombinant form of human α-L-iduronidase and is produced by recombinant DNA technology. Laronidase is indicated for long-term enzyme replacement therapy in patients with a confirmed diagnosis of Mucopolysaccharidosis I (MPS I; α-L-iduronidase deficiency) to treat the non-neurological manifestations of the disease.

Read more about Laronidase

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