Active Ingredient: Propofol
Propofol is a short-acting intravenous general anaesthetic for sedation for induction of general anaesthesia in adults and children over one month of age.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 1.5 milligrams propofol per kilogram of body weight and 2.5 milligrams propofol per kilogram of body weight, once every minute.
Propofol 1% may be used to induce anaesthesia by slow bolus injection or infusion.
In unpremedicated and premedicated patients, it is recommended that propofol should be titrated (approximately 40 mg every 10 seconds in an average healthy adult by bolus injection or infusion) against the response of the patient until the clinical signs show the onset of anaesthesia. Most adult patients aged less than about 55 years are likely to require 1.5 to 2.5 mg/kg of propofol. The total dose required can be reduced by lower rates of administration (20–50 mg/min). Over this age, the requirement will generally be less. In patients of ASA grades 3 and 4, lower rates of administration should be used (approximately 20 mg every 10 seconds).
In older people the dose requirement for induction of anaesthesia with propofol is reduced. The reduction should take account of the physical status and age of the patient. The reduced dose should be given at a slower rate and titrated against the response.
For:
In the case that patient age in months is ≥ 1 :
Intravenous, between 2.5 milligrams propofol per kilogram of body weight and 4 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
For induction of anaesthesia in children over 1 month of age, propofol 1% should be titrated slowly until clinical signs show the onset of anaesthesia. The dose should be adjusted according to age and/or body weight. Most patients over 8 years of age require approximately 2.5 mg/kg body weight of propofol 1% for induction of anaesthesia. In younger children, especially between the age of 1 month and 3 years, dose requirements may be higher (2.5–4 mg/kg body weight).
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