HIV-1 infection

Active Ingredient: Indinavir

Indication for Indinavir

Population group: only adults (18 - 65 years old)

Indinavir is indicated in combination with antiretroviral nucleoside analogues for the treatment of HIV-1 infected adults.

For this indication, competent medicine agencies globally authorize below treatments:

2400 mg in 2 divided doses daily

Route of admnistration


Defined daily dose

2,400 - 2,400 mg

Dosage regimen

From 800 To 800 mg 3 time(s) per day every day

Detailed description

The recommended dose of indinavir is 800 mg orally every 8 hours.

Data from published studies suggest that indinavir 400 mg in combination with ritonavir 100 mg, both administered orally twice daily, may be an alternative dosing regimen. The suggestion is based on limited published data.

A dose reduction of indinavir to 600 mg every 8 hours should be considered when administering itraconazole or ketoconazole concurrently.

Dosage considerations

For optimal absorption, indinavir should be administered without food but with water 1 hour before or 2 hours after a meal. Alternatively, indinavir may be administered with a low-fat, light meal.

Active ingredient


Indinavir inhibits recombinant HIV-1 and HIV-2 protease with an approximate tenfold selectivity for HIV-1 over HIV-2 proteinase. Indinavir binds reversibly to the protease active site and inhibits competitively the enzyme, thereby preventing cleavage of the viral precursor polyproteins that occurs during maturation of the newly formed viral particle.

Read more about Indinavir

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