Non-radiographic axial spondyloarthritis

Active Ingredient: Etanercept

Indication for Etanercept

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of adults with severe non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence, who have had an inadequate response to nonsteroidal anti-inflammatory drugs (NSAIDs).

For this indication, competent medicine agencies globally authorize below treatments:

25 mg twice weekly or 50 mg once weekly

For:

Dosage regimens

Regimen A: Oral, 25 milligrams etanercept, 2 times weekly.

Regimen B: Oral, 50 milligrams etanercept, once weekly.

Detailed description

25 mg etanercept administered twice weekly is the recommended dose. Alternatively, 50 mg administered once weekly has been shown to be safe and effective.

Available data suggest that a clinical response is usually achieved within 12 weeks of treatment. Continued therapy should be carefully reconsidered in a patient not responding within this time period.

Active ingredient

Etanercept

Etanercept is a competitive inhibitor of TNF binding to its cell surface receptors, and thereby inhibits the biological activity of TNF. The mechanism of action of etanercept is thought to be its competitive inhibition of TNF binding to cell surface TNFR, preventing TNF-mediated cellular responses by rendering TNF biologically inactive.

Read more about Etanercept

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