Major depression

Active Ingredient: Moclobemide

Indication for Moclobemide

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

300 mg daily for 1 week and 600 mg daily thereafter in 2-3 divided doses


Dosage regimens

Oral, 300 milligrams moclobemide, divided 2 to 3 times daily, over the duration of 1 week. Afterwards, oral, 600 milligrams moclobemide, divided 2 to 3 times daily.

Detailed description

The recommended initial dose is 300mg daily, usually administered in 2-3 divided doses. The dose may be increased up to 600mg/day depending on the severity of the depression.

The individual response may allow a reduction of the daily dose to 150mg.

The dose should not be raised until after the first week, as bioavailability increases during this period.

Treatment should continue for at least 4-6 weeks in order to assess the efficacy of the drug.

Elderly patients do not require a special dose adjustment.

Dosage considerations

It should be taken at the end of a meal.

Active ingredient


Moclobemide is an antidepressant which affects the monoaminergic cerebral neurotransmitter system by means of a reversible inhibition of monoamine oxidase preferentially of type A (RIMA).

Read more about Moclobemide

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