Sedation in intensive care

Active Ingredient: Midazolam

Indication for Midazolam

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For sedation by continuous infusion in patients in intensive care.

For this indication, competent medicine agencies globally authorize below treatments:

0.03-0.20 mg/kg/h

Route of admnistration


Defined daily dose

0.03 - 0.2 mg per kg of body weight

Dosage regimen

From 0.03 To 0.2 mg per kg of body weight once every day

Detailed description

Loading dose: For patients already sedated, a loading dose of midazolam is not required. To induce sedation, a loading dose of 0.03 – 0.3mg/kg is recommended, depending on the level of sedation required. This should be administered over a five minute period.

Maintenance dose: The dosage varies considerably. A dose between 0.03 – 0.2mg/kg per hour is recommended, commencing at the lower end of the range.

The dosage should be reduced or the loading dose should even be omitted in hypovolaemic, vasoconstricted and hypothermic patients.

Active ingredient


Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of midazolam to form water-soluble salts with acids.

Read more about Midazolam

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