Cardiovascular prevention

Active Ingredient: Simvastatin

Indication for Simvastatin

Population group: only adults (18 years old or older)
Therapeutic intent: Preventive action

Reduction of cardiovascular mortality and morbidity in patients with manifest atherosclerotic cardiovascular disease or diabetes mellitus, with either normal or increased cholesterol levels, as an adjunct to correction of other risk factors and other cardioprotective therapy.

For this indication, competent medicine agencies globally authorize below treatments:

20-40 mg once daily


Dosage regimens

Oral, between 20 milligrams simvastatin and 40 milligrams simvastatin, once daily at evening. The maximum allowed total dose is 80 milligrams simvastatin daily.

Detailed description

The dose range is 5-80 mg/day of simvastatin given orally as a single dose in the evening. Adjustments of dose, if required, should be made at intervals of not less than 4 weeks, to a maximum of 80 mg/day given as a single dose in the evening. The 80 mg dose is only recommended in patients with severe hypercholesterolaemia and at high risk for cardiovascular complications who have not achieved their treatment goals on lower doses and when the benefits are expected to outweigh the potential risks.

Cardiovascular prevention

The usual dose of simvastatin is 20 to 40 mg/day given as a single dose in the evening in patients at high risk of coronary heart disease (CHD, with or without hyperlipidaemia). Medicinal product therapy can be initiated simultaneously with diet and exercise. Adjustments of dose, if required, should be made as specified above.

Dosage considerations

It can be administered as a single dose in the evening.

Active ingredient


Simvastatin has a potent activity in inhibiting HMG-CoA reductase (3-hydroxy–3-ethylglutaryl-CoA-reductase). Simvastatin has been shown to reduce both normal and elevated LDL-C concentrations.

Read more about Simvastatin

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