Active Ingredient: Asfotase alfa
Asfotase alfa is indicated for long-term enzyme replacement therapy in patients with paediatric-onset hypophosphatasia to treat the bone manifestations of the disease.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
2 - 2 mg per kg of body weight
From 2 To 2 mg per kg of body weight once every 2 day(s)
Recommended dosage regimen of asfotase alfa is 2 mg/kg of body weight administered subcutaneously three times per week. Maximum recommended dose of asfotase alfa is 6 mg/kg/week.
If a dose of asfotase alfa is missed, a double dose should not be injected to make up for the missed dose.
Injections sites should be rotated and carefully monitored for signs of potential reactions.
Subcutaneous
1 - 1 mg per kg of body weight
From 1 To 1 mg per kg of body weight once every day
Recommended dosage regimen of asfotase alfa is 1 mg/kg of body weight administered subcutaneously six times per week. Maximum recommended dose of asfotase alfa is 6 mg/kg/week.
If a dose of asfotase alfa is missed, a double dose should not be injected to make up for the missed dose.
Injections sites should be rotated and carefully monitored for signs of potential reactions.
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