Duodenal ulcer, benign gastric ulcer

Active Ingredient: Ranitidine

Indication for Ranitidine

Population group: only children (1 year - 12 years old)

For this indication, competent medicine agencies globally authorize below treatments:

4-8 mg/kg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

4 - 8 mg per kg of body weight

Dosage regimen

From 2 To 4 mg per kg of body weight 2 time(s) per day every day

Detailed description

The recommended oral dose for the treatment of peptic ulcer in children is 4 mg/kg/day to 8 mg/kg/day administered as two divided doses to a maximum of 300 mg ranitidine per day for a duration of 4 weeks. For those patients with complete healing, another 4 weeks of therapy is indicated, as healing usually occurs after eight weeks of treatment.

2-6 mg/kg in 3-4 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

2 - 6 mg per kg of body weight

Dosage regimen

From 0.5 To 1.5 mg per kg of body weight 4 time(s) per day every day

Detailed description

Intravenous therapy in children with peptic ulcer disease is indicated only when oral therapy is not possible.

For acute treatment of peptic ulcer disease and gastro-oesophageal reflux in paediatric patients, ranitidine injection may be administered at doses that have been shown to be effective for these diseases in adults and effective for acid suppression in critically ill children. The initial dose (2.0 mg/kg or 2.5 mg/kg, maximum 50 mg) may be administered as a slow intravenous infusion over 10 minutes, either with a syringe pump followed by a 3 mL flush with normal saline over 5 min, or following dilution with normal saline to 20 mL. Maintenance of pH>4.0 can be achieved by intermittent infusion of 1.5 mg/kg every 6 h to 8 h. Alternatively treatment can be continuous, administering a loading dose of 0.45 mg/kg followed by a continuous infusion of 0.15 mg/kg/hr.

Active ingredient

Ranitidine

Ranitidine is a specific rapidly acting histamine H2-antagonist. It inhibits basal and stimulated secretion of gastric acid, reducing both the volume and the acid and pepsin content of the secretion. Ranitidine has a relatively long duration of action and so a single 150 mg dose effectively suppresses gastric acid secretion for twelve hours.

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