Angina pectoris

Active Ingredient: Verapamil

Indication for Verapamil

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Angina pectoris, including Prinzmetal’s angina (coronary spasm, vasospastic angina).

For this indication, competent medicine agencies globally authorize below treatments:

120 mg 3-4 times daily


Dosage regimens

Oral, 120 milligrams verapamil, 3 to 4 times daily to meals. The maximum allowed total dose is 480 milligrams verapamil daily.

Detailed description

For the treatment of angina, including Prinzmetal’s angina, the usual dose is 120 mg 3 to 4 times daily. Although 80 mg 3 times daily may be adequate in many patients with angina of effort, doses below 120 mg 3 times daily are unlikely to be effective in angina of rest and Prinzmetal’s angina.

Dosage considerations

Verapamil should be taken preferably with or shortly after meals.

Verapamil should not be taken with grapefruit juice.

Active ingredient


Verapamil inhibits the transmembrane influx of calcium ions into the heart and vascular smooth muscle cell. The myocardial oxygen demand is lowered directly as a result of the effect on the energy consuming metabolic processes of the myocardial cell and indirectly due to a reduction of the afterload. Due to its effect on coronary vascular smooth muscle, verapamil enhances myocardial blood flow, even in postโ€stenotic areas, and relieves coronary spasms. These properties contribute to the antiโ€ischaemic and antianginal efficacy of verapamil in all types of coronary artery disease.

Read more about Verapamil

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