Schizophrenia

Active Ingredient: Brexpiprazole

Indication for Brexpiprazole

Population group: only adults (18 - 65 years old)

Brexpiprazole is indicated for the treatment of schizophrenia in adult patients.

For this indication, competent medicine agencies globally authorize below treatments:

1-4 mg once daily

Route of admnistration

Oral

Defined daily dose

1 - 4 mg

Dosage regimen

From 1 To 4 mg once every day

Detailed description

The recommended starting dose for brexpiprazole is 1 mg once daily on days 1 to 4.

The recommended target dose range is 2 mg to 4 mg once daily.

Based on the patient’s clinical response and tolerability the brexpiprazole dose can be titrated to 2 mg once daily on day 5 through day 7 and then to 4 mg on day 8.

The maximum recommended daily dose is 4 mg.

Switching from other antipsychotics to brexpiprazole

When switching from other antipsychotics to brexpiprazole gradual cross-titration should be considered, with gradual discontinuation of the previous treatment while brexpiprazole treatment is initiated.

Switching to other antipsychotics from brexpiprazole

When switching to other antipsychotics from brexpiprazole, no gradual cross-titration is needed, the new antipsychotic should be initiated in its lowest dose while brexpiprazole is discontinued. It should be considered that plasma concentration of brexpiprazole will decline gradually and will be completely washed out in 1 to 2 weeks.

Dosage considerations

It can be taken with or without food.

Active ingredient

Brexpiprazole

Brexpiprazole is an atypical antipsychotic agent. The pharmacology of brexpiprazole is believed to be mediated by a modulatory activity at the serotonin and dopamine systems that combines partial agonist activity at serotonergic 5-HT1A and at dopaminergic D2 receptors with antagonist activity at serotonergic 5-HT2A receptors, with similar high affinities at all of these receptors.

Read more about Brexpiprazole

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