Mild to moderate essential hypertension

Active Ingredient: Moxonidine

Indication for Moxonidine

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.2-0.6 mg in 1-2 divided doses daily

Route of admnistration

Oral

Defined daily dose

0.2 - 0.6 mg

Dosage regimen

From 0.1 To 0.3 mg 2 time(s) per day every day

Detailed description

Adults

Treatment must be instituted with the lowest dosage of moxonidine. This means a daily dose of 0.2 mg moxonidine in the morning. If the therapeutic effect is insufficient, the dose can be increased after three weeks to 0.4 mg. This dose can be given as a single dose (to be taken in the morning) or as a divided daily dose (morning and evening). If the results are still insufficient after a further three weeks treatment, the dosage can be increased further to a maximum of 0.6 mg given divided in the morning and evening. A single dose of 0.4 mg Moxonidine and a daily dose of 0.6 mg Moxonidine should not be exceeded.

Older people

Provided that renal function is not impaired, dosage recommendation is the same as for adults.

Active ingredient

Moxonidine

Moxonidine has been shown to bind selectively to the I1-imidazoline receptors in the brain stem. These imidazoline-sensitive receptors are concentrated in the rostral ventrolateral medulla, an area which is of crucial importance for central control of the peripheral sympathetic nervous system. The result of this effect on the I1-imidazoline receptors has been apparent in reduced activity in the sympathetic nerves. (demonstrated for cardiac, splanchnic and renal sympathetic nerves).

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