Active Ingredient: Mavorixafor
Mavorixafor is indicated in patients 12 years of age and older for the treatment of WHIM syndrome (warts, hypogammaglobulinemia, infections and myelokathexis) to increase the number of circulating mature neutrophils and lymphocytes.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A, in the case that patient weight is > 50 kg :
Oral, 400 milligrams mavorixafor, once daily -30 minutes before breakfast.
Regimen B, in the case that patient weight is ≤ 50 kg :
Oral, 300 milligrams mavorixafor, once daily -30 minutes before breakfast.
The recommended dose is:
There are limited data on patients aged 65 years and older.
If a dose is missed, the next dose should be taken as scheduled. The patient should not take a double dose to make up for a missed dose.
Concomitant use of mavorixafor with strong or moderate CYP3A4 inhibitors When used concomitantly with a strong CYP3A4 inhibitor, daily dose should be reduced to 200 mg.
When used concomitantly with a strong CYP3A4 inhibitor, daily dose should be reduced to 200 mg. When used concomitantly with a moderate CYP3A4 inhibitor, adverse reactions that may be associated with an increase in mavorixafor exposure should be monitored more frequently, and the mavorixafor daily dose should be reduced by steps of 100 mg, as clinically necessary, but not to a dose less than 200 mg.
When used concomitantly with a P-gp inhibitor, adverse reactions that may be associated with an increase in mavorixafor exposure should be monitored more frequently, and the mavorixafor daily dose should be reduced by steps of 100 mg, as clinically necessary, but not to a dose less than 200 mg.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.