Colorectal cancer

Active Ingredient: Oxaliplatin

Indication for Oxaliplatin

Population group: only adults (18 years old or older)

Oxaliplatin in combination with 5-fluorouracil (5-FU) and folinic acid (FA) is indicated for:

  • Adjuvant treatment of stage III (Duke’s C) colon cancer after complete resection of primary tumor.
  • Treatment of metastatic colorectal cancer.

For this indication, competent medicine agencies globally authorize below treatments:

85 mg/m² once every 2 weeks

Route of admnistration


Defined daily dose

85 - 85 mg per m² of body surface area (BSA)

Dosage regimen

From 85 To 85 mg per m² of body surface area (BSA) once every 14 day(s)

Detailed description

The recommended dose for oxaliplatin in adjuvant setting is 85 mg/m² intravenously repeated every two weeks for 12 cycles (6 months).

The recommended dose for oxaliplatin in treatment of metastatic colorectal cancer is 85 mg/m² intravenously repeated every 2 weeks.

Dosage given should be adjusted according to tolerability.

Oxaliplatin should always be administered before fluoropyrimidines-i.e. 5-fluorouracil (5 FU).

Oxaliplatin is administered as a 2- to 6-hour intravenous infusion in 250 to 500 ml of 5% glucose solution (50mg/ml) to give a concentration between 0.2 mg/ml and 0.70 mg/ml; 0.7 mg/ml is the highest concentration in clinical practice for an oxaliplatin dose of 85 mg/m².

Oxaliplatin was mainly used in combination with continuous infusion 5-fluorouracil based regimens. For the two-weekly treatment schedule 5-fluorouracil regimens combining bolus and continuous infusion were used.

Dosage considerations

Oxaliplatin diluted in 250 to 500 ml of 5% glucose solution to give a concentration not less than 0.2 mg/ml must be infused via a central venous line or peripheral vein over 2 to 6 hours. Oxaliplatin infusion should always precede that of 5-fluorouracil.

Active ingredient


Oxaliplatin is an antineoplastic active substance belonging to a new class of platinum-based compounds in which the platinum atom is complexed with 1,2-diaminocyclohexane (“DACH”) and an oxalate group.

Read more about Oxaliplatin

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