Active Ingredient: Cetuximab
Cetuximab is indicated for the treatment of patients with squamous cell cancer of the head and neck in combination with platinum-based chemotherapy for recurrent and/or metastatic disease.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A :
Intravenous, 400 milligrams cetuximab per square meter of body surface, one dose, over the duration of 1 week. Afterwards, intravenous, 250 milligrams cetuximab per square meter of body surface, once weekly.
Regimen B :
Intravenous, 500 milligrams cetuximab, once every 2 weeks.
Prior to the first infusion, patients must receive premedication with an antihistamine and a corticosteroid at least 1 hour prior to administration of cetuximab. This premedication is recommended prior to all subsequent infusions.
In patients with recurrent and/or metastatic squamous cell cancer of the head and neck, cetuximab is used in combination with platinum-based chemotherapy followed by cetuximab as maintenance therapy until disease progression. Chemotherapy must not be administered earlier than 1 hour after the end of the cetuximab infusion.
Cetuximab may be administered in a weekly or every other week dose regimen.
Weekly dose regimen:
Cetuximab is administered once a week. The initial dose is 400 mg cetuximab per m² body surface area (BSA). All subsequent weekly doses are 250 mg/m² each.
Biweekly dose regimen:
Cetuximab is administered once every other week. Each dose is 500 mg cetuximab per m² body surface area.
No dose adjustment is required in older people, but the experience is limited in patients 75 years of age and above.
Cetuximab is administered intravenously with an infusion pump, gravity drip or a syringe pump. The initial dose should be given slowly to minimize risk of infusion related reactions.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.