Active Ingredient: Nivolumab
Nivolumab as monotherapy is indicated for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma after autologous stem cell transplant (ASCT) and treatment with brentuximab vedotin.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 240 milligrams nivolumab, once every 2 weeks.
The recommended dose is 240 mg every 2 weeks.
Treatment with nivolumab should be continued as long as clinical benefit is observed or until treatment is no longer tolerated by the patient (and up to maximum duration of therapy if specified for an indication).
Atypical responses (i.e., an initial transient increase in tumour size or small new lesions within the first few months followed by tumour shrinkage) have been observed. It is recommended to continue treatment with nivolumab for clinically stable patients with initial evidence of disease progression until disease progression is confirmed.
Dose escalation or reduction is not recommended for nivolumab. Dosing delay or discontinuation may be required based on individual safety and tolerability.
Nivolumab should be permanently discontinued for:
If dosing is resumed after a delay, monotherapy could be resumed based on the evaluation of the individual patient.
The recommended dose of OPDIVO is either nivolumab 240 mg every 2 weeks
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