Chronic myelogenous leukaemia

Active Ingredient: Interferon, alfa-2b

Indication for Interferon, alfa-2b

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

4-5 million IU once daily

Route of admnistration


Defined daily dose

4,000,000 - 5,000,000 [iU]

Dosage regimen

From 4,000,000 To 5,000,000 [iU] once every day

Detailed description

The recommended dose of interferon alpha-2b is 4 to 5 million IU/m² administered daily subcutaneously. Some patients have been shown to benefit from interferon alpha-2b 5 million IU/m² administered daily subcutaneously in association with cytarabine (Ara-C) 20 mg/m² administered daily subcutaneously for 10 days per month (up to a maximum daily dose of 40 mg). When the white blood cell count is controlled, administer the maximum tolerated dose of interferon alpha-2b (4 to 5 million IU/m² daily) to maintain haematological remission.

Interferon alpha-2b treatment must be discontinued after 8 to 12 weeks of treatment if at least a partial haematological remission or a clinically meaningful cytoreduction has not been achieved.

Active ingredient

Interferon, alfa-2b

Recombinant interferon alfa-2b is a sterile, stable, formulation of highly purified interferon alfa-2b produced by recombinant DNA techniques. Interferons exert their cellular activities by binding to specific membrane receptors on the cell surface. Recombinant interferon alfa-2b has exhibited antiproliferative effects in studies employing both animal and human cell culture systems as well as human tumour xenografts in animals. It has demonstrated significant immunomodulatory activity in vitro.

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