Active Ingredient: Dornase alfa
Management of cystic fibrosis patients with a forced vital capacity (FVC) of greater than 40% of predicted and over 5 years of age to improve pulmonary function.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Respiratory (Inhalation), 2.5 milligrams dornase alfa, once daily. The maximum allowed total dose is 5 milligrams dornase alfa daily.
2.5 mg (corresponding to 2500 U) deoxyribonuclease l by inhalation once daily.
Some patients over the age of 21 years may benefit from twice daily dosage.
Most patients gain optimal benefit from regular daily use of dornase alpha. In studies in which dornase alpha was given in an intermittent regimen, improvement in pulmonary function was lost on cessation of therapy. Patients should therefore be advised to take their medication every day without a break.
Patients should continue their regular medical care, including their standard regimen of chest physiotherapy.
Administration can be safely continued in patients who experience exacerbation of respiratory tract infection.
Safety and efficacy have not yet been established in patients with forced vital capacity less than 40% of predicted.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
