Selegiline is indicated for the treatment of Parkinson’s disease, or symptomatic parkinsonism. It is used as an adjunct to levodopa (with or without decarboxylase inhibitor). Selegiline in combination with maximal levodopa therapy is indicated particularly in patients who experience fluctuations in their condition such as ‘end-dose’ type fluctuations, ‘on-off’ symptoms or other dyskinesias.
For this indication, competent medicine agencies globally authorize below treatments:
For: Adults (18-64) Elders (65+)
Regimen A: Oral, 5 milligrams, once daily at morning. Afterwards, oral, 10 milligrams, once daily at morning.
Regimen B: Oral, 5 milligrams, once daily at morning. Afterwards, oral, 5 milligrams, 2 times daily to meals.
10 mg daily as an adjunct to levodopa or levodopa/peripheral decarboxylase inhibitor.
When selegiline is added to a levodopa regimen it is possible to reduce the levodopa dosage by an average of 10-30%. Reduction of the levodopa dose should be gradual in steps of 10% every 3 to 4 days.
Selegiline may be administered either as a single dose in the morning or in two divided doses of 5 mg, taken at breakfast and lunch.
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