Parkinson's disease

Active Ingredient: Selegiline

Indication for Selegiline

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct - intent

Selegiline is indicated for the treatment of Parkinson’s disease, or symptomatic parkinsonism. It is used as an adjunct to levodopa (with or without decarboxylase inhibitor). Selegiline in combination with maximal levodopa therapy is indicated particularly in patients who experience fluctuations in their condition such as ‘end-dose’ type fluctuations, ‘on-off’ symptoms or other dyskinesias.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg daily


Dosage regimens

Regimen A: Oral, 5 milligrams selegiline, once daily at morning. Afterwards, oral, 10 milligrams selegiline, once daily at morning.

Regimen B: Oral, 5 milligrams selegiline, once daily at morning. Afterwards, oral, 5 milligrams selegiline, 2 times daily to meals.

Detailed description

10 mg daily as an adjunct to levodopa or levodopa/peripheral decarboxylase inhibitor.

When selegiline is added to a levodopa regimen it is possible to reduce the levodopa dosage by an average of 10-30%. Reduction of the levodopa dose should be gradual in steps of 10% every 3 to 4 days.

Selegiline may be administered either as a single dose in the morning or in two divided doses of 5 mg, taken at breakfast and lunch.

Active ingredient


Selegiline is a selective MAO-B-inhibitor which prevents dopamine breakdown in the brain. It also inhibits the reuptake of dopamine at the presynaptic dopamine receptor. These effects potentiate dopaminergic function in the brain and help to even out and prolong the effect of exogenous and endogenous dopamine. Thus, selegiline potentiates and prolongs the effect of levodopa in the treatment of parkinsonism.

Read more about Selegiline

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