VERAPAMIL Film-coated tablets Ref.[7556] Active ingredients: Verapamil

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2019  Publisher: Accord-UK Ltd (Trading style: Accord), Whiddon Valley, Barnstaple, Devon, EX32 8NS

Product name and form

VERAPAMIL TABLETS BP 40mg.

Pharmaceutical Form

Yellow film-coated tablets.

Yellow, circular, biconvex film-coated tablets, impressed “C” on one face and the identifying letters “VR” on the reverse.

Tablet diameter: 6.18-6.82mm.

Qualitative and quantitative composition

Each tablet contains 40mg Verapamil Hydrochloride PhEur.

Excipient with known effect: Sunset yellow aluminium lake (E110).

For the full list of excipients, see section 6.1.

Active Ingredient Description
Verapamil

Verapamil is a phenylalkylamine calcium antagonist which blocks the inward movement of calcium ions in cardiac muscle cells, in smooth muscle cells of the coronary and systemic arteries and in cells of the intracardiac conduction system. It lowers heart rate, increases myocardial perfusion and reduces coronary spasm. Because of its effect on the movement of calcium in the intracardiac conduction system, verapamil reduces automaticity, decreases conduction velocity and increases the refractory period.

List of Excipients

Also contains:

Croscarmellose sodium
Magnesium stearate
Maize starch
Propylene glycol
Sunset yellow aluminium lake (E110)
Quinoline yellow aluminium lake (E104)
Titanium dioxide (E171)
Microcrystalline cellulose (E460)
Hydroxypropylcellulose (E463)
Methylhydroxypropylcellulose (E464)
Purified talc (E553)

Pack sizes and marketing

The product containers are rigid injection moulded polypropylene or injection blow-moulded polyethylene containers and snap-on polyethylene lids; in case any supply difficulties should arise the alternative is amber glass containers with screw caps.

The product may also be supplied in blister packs and cartons:

  • Carton: Printed carton manufactured from white folding box board.
  • Blister pack: (i) 250ยตm white rigid PVC. (ii) Surface printed 20ยตm hard temper aluminium foil with 5-6g/M2 PVC and PVdC compatible heat seal lacquer on the reverse side.

Pack size: 28s, 30s, 56s, 60s, 84s, 90s, 100s, 112s, 120s, 168s, 180s, 250s, 500s, 1000s.

Product may also be supplied in bulk packs, for reassembly purposes only, in polybags contained in tins, skillets or polybuckets filled with suitable cushioning material. Bulk packs are included for temporary storage of the finished product before final packaging into the proposed marketing containers.

Maximum size of bulk packs: 50,000.

Marketing authorization holder

Accord-UK Ltd (Trading style: Accord), Whiddon Valley, Barnstaple, Devon, EX32 8NS

Marketing authorization dates and numbers

PL 0142/0281

Date of first authorisation: 18th September 1989
Date of latest renewal: 7th July 1997

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