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ATC Group: A05AA01 Chenodeoxycholic acid

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A05
Bile and liver therapy
3
A05A
Bile therapy
4
A05AA
Bile acid preparations
5
A05AA01
Chenodeoxycholic acid

Active Ingredients

Chemical substance
Description
Chenodeoxycholic acid

Exogenous chenodeoxycholic acid is used as replacement therapy to restore the feedback inhibition lost due to the deficiency/absence of endogenous chenodeoxycholic acid. In CTX, deficiency of chenodeoxycholic acid causes a lack of feedback of cholesterol 7 alpha hydroxylase (CYP7A1) and HMG CoA reductase, causing increased production of atypical bile acids, bile alcohols and cholestanol that lead to the pathological consequences of the condition.