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ATC Group: J04B Drugs for treatment of lepra

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
J
Antiinfectives for systemic use
2
J04
Antimycobacterials
3
J04B
Drugs for treatment of lepra

Contents

Code
Title
J04BA
Drugs for treatment of lepra

Active Ingredients

Chemical substance
Description
Aldesulfone

Sulfoxone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Aldesulfone sodium (or sulfoxone) is an antibiotic used in the treatment of leprosy.

Chlofazimine

Clofazimine is an antimycobacterial drug. Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen’s bacillus). Clofazimine inhibits mycobacterial growth and binds preferentially to mycobacterial DNA.

Dapsone

Dapsone is a sulfone active against a wide range of bacteria. Dapsones mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms.

Monographs

Monograph
Type
Country
DAPSONE Tablet
MPI, EU: SmPC
UK