ATC Group: R06AB Substituted alkylamines

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of R06AB in the ATC hierarchy

Level Code Title
1 R Respiratory system
2 R06 Antihistamines for systemic use
3 R06A Antihistamines for systemic use
4 R06AB Substituted alkylamines

Group R06AB contents

Code Title
R06AB01 Brompheniramine
R06AB02 Dexchlorpheniramine
R06AB03 Dimetindene
R06AB04 Chlorphenamine
R06AB05 Pheniramine
R06AB06 Dexbrompheniramine
R06AB07 Talastine
R06AB51 Brompheniramine, combinations
R06AB52 Dexchlorpheniramine, combinations
R06AB54 Chlorphenamine, combinations
R06AB56 Dexbrompheniramine, combinations

Active ingredients in R06AB

Active Ingredient Description
Brompheniramine
Chlorphenamine

Chlorphenamine is a potent antihistamine (H1-antagonist). Antihistamines diminish or abolish the actions of histamine in the body by competitive reversible blockade of histamine H1-receptor sites on tissues. Chlorphenamine also has anticholinergic activity.

Dexchlorpheniramine

Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects.

Dimetindene

Dimetindene is an antihistaminic of the alkylamine group. Its action is the result of the capture of histamine Η1 subunits. It has mild anticholinergic and sedative action.

Pheniramine

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