The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | R | Respiratory system | |
| 2 | R07 | Other respiratory system products | |
| 3 | R07A | Other respiratory system products | |
| 4 | R07AX | Other respiratory system products | |
| 5 | R07AX32 | Ivacaftor, tezacaftor and elexacaftor |
| Active Ingredient | Description | |
|---|---|---|
| Ivacaftor, Tezacaftor and Elexacaftor |
Elexacaftor and tezacaftor are CFTR correctors that bind to different sites on the CFTR protein and have an additive effect in facilitating the cellular processing and trafficking of F508del-CFTR to increase the amount of CFTR protein delivered to the cell surface compared to either molecule alone. Ivacaftor potentiates the channel open probability (or gating) of the CFTR protein at the cell surface. The combined effect of elexacaftor, tezacaftor and ivacaftor is increased quantity and function of F508del-CFTR at the cell surface, resulting in increased CFTR activity as measured by CFTR mediated chloride transport. |
| Title | Information Source | Document Type | |
|---|---|---|---|
| KAFTRIO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| KAFTRIO Granules | European Medicines Agency (EU) | MPI, EU: SmPC |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.
