This brand name is authorized in Germany, Ireland, Lithuania, Singapore
The drug ACTONEL PLUS CALCIUM & D contains a combination of these active pharmaceutical ingredients (APIs):
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1
Risedronic acid
UNII OFG5EXG60L - RISEDRONATE SODIUM
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Risedronic acid is a pyridinyl bisphosphonate that binds to bone hydroxyapatite and inhibits osteoclast-mediated bone resorption. The bone turnover is reduced while the osteoblast activity and bone mineralisation is preserved. |
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2
Calcium carbonate
UNII H0G9379FGK - CALCIUM CARBONATE
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Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. |
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3
Vitamin D3
UNII 1C6V77QF41 - CHOLECALCIFEROL
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In its biologically active form vitamin D3 stimulates intestinal calcium absorption, incorporation of calcium into the osteoid, and release of calcium from bone tissue. In the small intestine it promotes rapid and delayed calcium uptake. The passive and active transport of phosphate is also stimulated. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| M05BB04 | Risedronic acid, calcium and colecalciferol, sequential | M Musculo-skeletal system → M05 Drugs for treatment of bone diseases → M05B Drugs affecting bone structure and mineralization → M05BB Bisphosphonates, combinations |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: DE | Bundesinstitut für Arzneimittel und Medizinprodukte | Identifier(s): 02061537, 02061804 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1088992 |
| Country: SG | Health Sciences Authority | Identifier(s): 13818P |
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