ADCETRIS

Found in: Austria Australia Brazil Canada Cyprus Spain France Hong Kong Lithuania Netherlands Singapore United Kingdom United States

Active ingredients

UNII: 7XL5ISS668 - BRENTUXIMAB VEDOTIN

Brentuximab vedotin is an antibody drug conjugate (ADC) that delivers an antineoplastic agent that results in apoptotic cell death selectively in CD30-expressing tumour cells. Nonclinical data suggest that the biological activity of brentuximab vedotin results from a multi-step process. Binding of the ADC to CD30 on the cell surface initiates internalisation of the ADC-CD30 complex, which then traffics to the lysosomal compartment. Within the cell, a single defined active species, MMAE, is released via proteolytic cleavage. Binding of MMAE to tubulin disrupts the microtubule network within the cell, induces cell cycle arrest and results in apoptotic death of the CD30-expressing tumour cell.

Medicine classification

ATC Code
Title
Class
Brentuximab vedotin
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FX Other monoclonal antibodies

Product monographs

Monograph
Type
Country

Identifiers

Authority
Identifier(s)
FDA, National Drug Code (US)
Identifier(s): 51144-050
Health Products and Food Branch (CA)
Identifier(s): 02401347
Health Sciences Authority (SG)
Identifier(s): 14477P
Pharmaceutical Benefits Scheme (AU)
Identifier(s): 10166C, 10171H, 10172J, 10180T, 11067L, 11073T, 11079D, 11080E, 11086L, 11087M, 11089P, 11096B, 11651F, 11660Q, 11661R, 11664X
Z-Index G-Standaard PRK (NL)
Identifier(s): 103993
Base de données publique des médicaments (FR)
Identifier(s): 68438457
Centro de información online de medicamentos de la AEMPS (ES)
Identifier(s): 112794001, 112794001IP
Medicines & Healthcare Products Regulatory Agency (GB)
Identifier(s): 215727
Valstybinė vaistų kontrolės tarnyba (LT)
Identifier(s): 1068355, 1082316
Department of Health Drug Office (HK)
Identifier(s): 63483
Câmara de Regulação do Mercado de Medicamentos (BR)
Identifier(s): 501115010024502