ADCETRIS

Brand name authorized in: Austria Australia Brazil Canada Cyprus Spain Finland France Hong Kong Ireland Lithuania Netherlands Poland Singapore United Kingdom United States

Active ingredients

The drug ADCETRIS contains one active pharmaceutical ingredient (API):

1 Brentuximab vedotin
UNII 7XL5ISS668 - BRENTUXIMAB VEDOTIN

Brentuximab vedotin is an antibody drug conjugate (ADC) that delivers an antineoplastic agent that results in apoptotic cell death selectively in CD30-expressing tumour cells. Nonclinical data suggest that the biological activity of brentuximab vedotin results from a multi-step process. Binding of the ADC to CD30 on the cell surface initiates internalisation of the ADC-CD30 complex, which then traffics to the lysosomal compartment. Within the cell, a single defined active species, MMAE, is released via proteolytic cleavage. Binding of MMAE to tubulin disrupts the microtubule network within the cell, induces cell cycle arrest and results in apoptotic death of the CD30-expressing tumour cell.

Read about Brentuximab vedotin

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code
Group title
Classification
Brentuximab vedotin
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FX Other monoclonal antibodies
Discover more medicines within L01FX05

Medication package inserts

Below package inserts are available for further reading:

Title
Type
Country
Summary of product characteristics (SPC)

Unique identifiers

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country
Identification scheme
Identifier(s)
AU
Pharmaceutical Benefits Scheme
Identifier(s): 10166C, 10171H, 10172J, 10180T, 11067L, 11073T, 11079D, 11080E, 11086L, 11087M, 11089P, 11096B, 11651F, 11660Q, 11661R, 11664X
BR
Câmara de Regulação do Mercado de Medicamentos
Identifier(s): 501115010024502
CA
Health Products and Food Branch
Identifier(s): 02401347
ES
Centro de información online de medicamentos de la AEMPS
Identifier(s): 112794001, 112794001IP
FI
Lääkealan turvallisuus- ja kehittämiskeskus
Identifier(s): 095175
FR
Base de données publique des médicaments
Identifier(s): 68438457
GB
Medicines & Healthcare Products Regulatory Agency
Identifier(s): 215727
HK
Department of Health Drug Office
Identifier(s): 63483
LT
Valstybinė vaistų kontrolės tarnyba
Identifier(s): 1068355, 1082316
NL
Z-Index G-Standaard, PRK
Identifier(s): 103993
PL
Rejestru Produktów Leczniczych
Identifier(s): 100285152
SG
Health Sciences Authority
Identifier(s): 14477P
US
FDA, National Drug Code
Identifier(s): 51144-050