Brentuximab vedotin

Active ingredient description

Brentuximab vedotin is an antibody drug conjugate (ADC) that delivers an antineoplastic agent that results in apoptotic cell death selectively in CD30-expressing tumour cells. Nonclinical data suggest that the biological activity of brentuximab vedotin results from a multi-step process. Binding of the ADC to CD30 on the cell surface initiates internalisation of the ADC-CD30 complex, which then traffics to the lysosomal compartment. Within the cell, a single defined active species, MMAE, is released via proteolytic cleavage. Binding of MMAE to tubulin disrupts the microtubule network within the cell, induces cell cycle arrest and results in apoptotic death of the CD30-expressing tumour cell.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01FX05 Brentuximab vedotin L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FX Other monoclonal antibodies
Discover more medicines within L01FX05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ADCETRIS Powder for concentrate for solution European Medicines Agency (EU) MPI, EU: SmPC

External identifiers

CAS Substance: 914088-09-8
DrugBank Drug: DB08870
KEGG Drug: D09587
RxNorm Ingredient: 1147320
SNOMED-CT Concept: 713395006
Brentuximab vedotin (substance)
UNII Identifier: 7XL5ISS668
BRENTUXIMAB VEDOTIN

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