COMBIRON FOLICO

This brand name is authorized in Brazil, Ecuador

Active ingredients

The drug COMBIRON FOLICO contains a combination of these active pharmaceutical ingredients (APIs):

1 Niacinamide
UNII 25X51I8RD4 - NIACINAMIDE
Read about Niacinamide
2 Vitamin B1
UNII X66NSO3N35 - THIAMINE

Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.

Read about Vitamin B1
3 Pantothenic acid
UNII 568ET80C3D - CALCIUM PANTOTHENATE

Pantothenic acid is incorporated into co-enzyme A and is involved in metabolic pathways involving acetylation which includes detoxification of drug molecules and biosynthesis of cholesterol, steroid hormones, mucopolysaccharides and acetylcholine. CoA has an essential function in lipid metabolism.

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4 Riboflavin
UNII TLM2976OFR - RIBOFLAVIN

Riboflavine is phosphorylated to flavine mononucleotide and flavine adenine dinucleotide which act as co-enzymes in the respiratory chain and in oxidative phosphorylation. Riboflavine deficiency presents with ocular symptoms, as well as lesions on the lips and at angles of the mouth.

Read about Riboflavin
5 Pyridoxine
UNII 68Y4CF58BV - PYRIDOXINE HYDROCHLORIDE

Pyridoxine hydrochloride is Vitamin B6. It is converted to pyridoxal phosphate which is the co-enzyme for a variety of metabolic transformations. It is essential for human nutrition.

Read about Pyridoxine
6 Ferrocarbonyl
UNII 6WQ62TAQ6Z - IRON PENTACARBONYL
7 Folic acid
UNII 935E97BOY8 - FOLIC ACID

Folic acid is a member of the vitamin B group which is reduced in the body to tetrahydrofolate, a co-enzyme active in several metabolic processes and produces a haemopoietic response in nutritional megaloblastic anaemias. Folic acid is rapidly absorbed and widely distributed in body tissues.

Read about Folic acid
8 Vitamin B12
UNII P6YC3EG204 - CYANOCOBALAMIN

Hydroxocobalamin is used in the treatment and prevention of Vitamin B12 deficiency. For adults, the daily requirement of Vitamin B12 is probably about 1 to 2 micrograms and this amount is present in most normal diets. However, Vitamin B12 only occurs in animal products, not in vegetables, and therefore strict vegetarian or vegan diets that exclude dairy products may provide an inadequate amount, although a deficiency may not be apparent for many years.

Read about Vitamin B12

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
A11JC Vitamins, other combinations A Alimentary tract and metabolism → A11 Vitamins → A11J Other vitamin products, combinations
Discover more medicines within A11JC

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: BR Câmara de Regulação do Mercado de Medicamentos Identifier(s): 500512101118418, 500512102114416
Country: EC Agencia Nacional de Regulación, Control y Vigilancia Sanitaria Identifier(s): 1712-MEE-0116

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