Chemical formula: C₁₂H₁₇N₄OS+ Molecular mass: 265.355 g/mol PubChem compound: 1130
Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A11DA01 | Thiamine (vit B1) | A Alimentary tract and metabolism → A11 Vitamins → A11D Vitamin B1, plain and in combination with vitamin B6 and B12 → A11DA Vitamin B1, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| THIAMINE HYDROCHLORIDE Tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Vitamin B1 is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)Israel (IL)Japan (JP)
Lithuania (LT)
Malta (MT)
Mexico (MX)
Netherlands (NL)New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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