Vitamin B1 Other names: Thiamine

Chemical formula: C₁₂H₁₇N₄OS+  Molecular mass: 265.355 g/mol  PubChem compound: 1130

Active ingredient description

Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A11DA01 Thiamine (vit B1) A Alimentary tract and metabolism → A11 Vitamins → A11D Vitamin B1, plain and in combination with vitamin B6 and B12 → A11DA Vitamin B1, plain
Discover more medicines within A11DA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
THIAMINE HYDROCHLORIDE Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 532-43-4
CAS Substance: 59-43-8
CAS Substance: 67-03-8
DrugBank Drug: DB00152
KEGG Drug: D08580
PubChem Compound: 1130
RxNorm Ingredient: 10454
SNOMED-CT Concept: 259659006
Thiamine (substance)
UNII Identifier: X66NSO3N35

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.