This brand name is authorized in Austria, Estonia, France, Croatia, Ireland, Italy, Lithuania
The drug KAPRUVIA contains one active pharmaceutical ingredient (API):
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Difelikefalin
UNII 0P70AR5BYB - DIFELIKEFALIN ACETATE
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Difelikefalin is a selective kappa opioid receptor agonist with low central nervous system penetration. The pathophysiology of chronic kidney disease-associated pruritus is thought to be multifactorial, including systemic inflammation and an imbalance in the endogenous opioid system (e.g., overexpression of mu opioid receptors and concomitant downregulation of kappa opioid receptors). The activation of kappa opioid receptors on peripheral sensory neurons and immune cells by difelikefalin are considered mechanistically responsible for the antipruritic and anti-inflammatory effects. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| KAPRUVIA Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AX04 | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AX Other therapeutic products | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1882076, 1882087 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 60144119 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 050051010, 050051022 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1094636, 1094637 |
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