This brand name is authorized in South Africa
The drug LENIZAK contains a combination of these active pharmaceutical ingredients (APIs):
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1
Dexketoprofen
UNII 6KD9E78X68 - DEXKETOPROFEN
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Dexketoprofen belongs to the non-steroidal anti-inflammatory group of drugs. The mechanism of action of Dexketoprofen is related to the reduction of prostaglandin synthesis by the inhibition of cyclooxygenase pathway. Furthermore, the inhibition of the synthesis of prostaglandins could affect other inflammation mediators such as kinins, causing an indirect action which would be additional to the direct action. |
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2
Tramadol
UNII 9N7R477WCK - TRAMADOL HYDROCHLORIDE
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Tramadol, a cyclohexanol derivative, is a centrally acting opioid analgesic. It is a non-selective pure agonist at μ, δ and κ opioid receptors with a higher affinity for the μ receptor. Other mechanisms which contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| LENIZAK Film-coated tablet | Health Products Regulatory Authority (ZA) | MPI, Generic |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N02AJ14 | Tramadol and dexketoprofen | N Nervous system → N02 Analgesics → N02A Opioids → N02AJ Opioids in combination with non-opioid analgesics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 54/2.8/0539.538 |
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