Tramadol Other names: Tramadol hydrochloride

Chemical formula: C₁₆H₂₅NO₂  Molecular mass: 263.381 g/mol  PubChem compound: 33741

Active ingredient description

Tramadol, a cyclohexanol derivative, is a centrally acting opioid analgesic. It is a non-selective pure agonist at μ, δ and κ opioid receptors with a higher affinity for the μ receptor. Other mechanisms which contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N02AX02 Tramadol N Nervous system → N02 Analgesics → N02A Opioids → N02AX Other opioids
Discover more medicines within N02AX02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TRAMADOL Capsule, hard Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
TRAMAL Capsule, Solution for injection, Tablet Medicines and Medical Devices Safety Authority (NZ) MPI, EU: SmPC
TRAMADOL Solution for injection or infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ULTRAM Coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 22204-88-2
CAS Substance: 27203-92-5
DrugBank Drug: DB00193
KEGG Drug: D08623
PubChem Compound: 33741
RxNorm Ingredient: 10689
SNOMED-CT Concept: 386858008
Tramadol (substance)
UNII Identifier: 39J1LGJ30J
TRAMADOL

Medicines

Tramadol is an active ingredient of these brands:

United States (US)

  • CONZIP as TRAMADOL HYDROCHLORIDE
  • QDOLO as TRAMADOL HYDROCHLORIDE
  • ULTRAM as TRAMADOL HYDROCHLORIDE

  • (combination) ULTRACET as TRAMADOL HYDROCHLORIDE

Australia (AU)

  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMEDO as TRAMADOL HYDROCHLORIDE
  • ZYDOL as TRAMADOL HYDROCHLORIDE

Austria (AT)

Brazil (BR)

  • GESICO as TRAMADOL HYDROCHLORIDE
  • KELTIX as TRAMADOL HYDROCHLORIDE
  • NOVOTRAM as TRAMADOL HYDROCHLORIDE
  • RAPITRAM as TRAMADOL HYDROCHLORIDE
  • SENSITRAM as TRAMADOL HYDROCHLORIDE
  • TIMASEN SR as TRAMADOL HYDROCHLORIDE
  • TRAMADON as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAUM as TRAMADOL HYDROCHLORIDE
  • UNIDOL as TRAMADOL HYDROCHLORIDE

  • (combination) ADORLAN as TRAMADOL HYDROCHLORIDE
  • (combination) ATRACE as TRAMADOL HYDROCHLORIDE
  • (combination) DAISAN as TRAMADOL HYDROCHLORIDE
  • (combination) GESICO DUO as TRAMADOL HYDROCHLORIDE
  • (combination) NOVOTRAM PAR as TRAMADOL HYDROCHLORIDE
  • (combination) PARATRAM as TRAMADOL HYDROCHLORIDE
  • (combination) REVANGE as TRAMADOL HYDROCHLORIDE
  • (combination) TILESTAL as TRAMADOL HYDROCHLORIDE
  • (combination) ULTRACET as TRAMADOL HYDROCHLORIDE

Canada (CA)

  • DURELA as TRAMADOL HYDROCHLORIDE
  • RALIVIA as TRAMADOL HYDROCHLORIDE
  • TRIDURAL as TRAMADOL HYDROCHLORIDE
  • ZYTRAM as TRAMADOL HYDROCHLORIDE

Croatia (HR)

  • LUMIDOL as TRAMADOL HYDROCHLORIDE
  • TRAMADOLOR as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE

  • (combination) DORETA as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE
  • (combination) ZARACET as TRAMADOL HYDROCHLORIDE
  • (combination) ZOTRAMID as TRAMADOL HYDROCHLORIDE

Cyprus (CY)

  • MABRON as TRAMADOL HYDROCHLORIDE
  • ROFY as TRAMADOL HYDROCHLORIDE
  • TRAMADEX as TRAMADOL HYDROCHLORIDE

  • (combination) MEDOTRAMOL as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE

Ecuador (EC)

  • BUDOL as TRAMADOL HYDROCHLORIDE
  • NAXODOL as TRAMADOL HYDROCHLORIDE
  • RAMGIC as TRAMADOL HYDROCHLORIDE
  • TRADOL as TRAMADOL HYDROCHLORIDE
  • TRADOXIL as TRAMADOL HYDROCHLORIDE
  • TRAMADON as TRAMADOL HYDROCHLORIDE
  • TRAMADOXIAL
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMEDIF as TRAMADOL HYDROCHLORIDE

  • (combination) ACROGESICO as TRAMADOL HYDROCHLORIDE
  • (combination) ADORLAN as TRAMADOL HYDROCHLORIDE
  • (combination) ALTROM ADVANCE as TRAMADOL HYDROCHLORIDE
  • (combination) ANALGAN TRAM as TRAMADOL HYDROCHLORIDE
  • (combination) BERALDOL as TRAMADOL HYDROCHLORIDE
  • (combination) BERALGEM as TRAMADOL HYDROCHLORIDE
  • (combination) BETASUN as TRAMADOL HYDROCHLORIDE
  • (combination) DALIVIUM TRAMAX as TRAMADOL HYDROCHLORIDE
  • (combination) DICASEN as TRAMADOL HYDROCHLORIDE
  • (combination) DOLANTAG as TRAMADOL HYDROCHLORIDE
  • (combination) DOLGENAL DUO as TRAMADOL HYDROCHLORIDE
  • (combination) DURAPAIN as TRAMADOL HYDROCHLORIDE
  • (combination) EUTRADIC as TRAMADOL HYDROCHLORIDE
  • (combination) LENIVEL-T as TRAMADOL HYDROCHLORIDE
  • (combination) MATRIX as TRAMADOL HYDROCHLORIDE
  • (combination) METAGESIC as TRAMADOL HYDROCHLORIDE
  • (combination) NAXODOL PLUS as TRAMADOL HYDROCHLORIDE
  • (combination) NORMOTEMP TRAM as TRAMADOL HYDROCHLORIDE
  • (combination) PARALGEN TRAM as TRAMADOL HYDROCHLORIDE
  • (combination) PARTRAMAXX as TRAMADOL HYDROCHLORIDE
  • (combination) PREBICTAL DUO as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) SUPRADOL DUET as TRAMADOL HYDROCHLORIDE
  • (combination) TRADIOL as TRAMADOL HYDROCHLORIDE
  • (combination) TRADOXIL D as TRAMADOL HYDROCHLORIDE
  • (combination) TRALEX as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMACET as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMALIV as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMEDIF COMPUESTO as TRAMADOL HYDROCHLORIDE
  • (combination) TRAPARCIN as TRAMADOL HYDROCHLORIDE
  • (combination) ZAFIN as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE
  • (combination) ZIGNET PLUS as TRAMADOL HYDROCHLORIDE

Estonia (EE)

  • AWARDIX as TRAMADOL HYDROCHLORIDE
  • MABRON as TRAMADOL HYDROCHLORIDE
  • OLTERON as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE

  • (combination) CLOCINOL as TRAMADOL HYDROCHLORIDE
  • (combination) DORETA as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMCET as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

  • ACUGESIC as TRAMADOL HYDROCHLORIDE
  • KOPAIN as TRAMADOL HYDROCHLORIDE
  • KORIDOL as TRAMADOL HYDROCHLORIDE
  • LUCIDOL as TRAMADOL HYDROCHLORIDE
  • MABRON as TRAMADOL HYDROCHLORIDE
  • MYOTRAM as TRAMADOL HYDROCHLORIDE
  • PAINDOL as TRAMADOL HYDROCHLORIDE
  • PENGESIC as TRAMADOL HYDROCHLORIDE
  • PINOREC as TRAMADOL HYDROCHLORIDE
  • SEFMAL as TRAMADOL HYDROCHLORIDE
  • TRABILIN as TRAMADOL HYDROCHLORIDE
  • TRADOLGESIC as TRAMADOL HYDROCHLORIDE
  • TRADYL as TRAMADOL HYDROCHLORIDE
  • TRAMADA as TRAMADOL HYDROCHLORIDE
  • TRAMO as TRAMADOL HYDROCHLORIDE
  • TRASIC as TRAMADOL HYDROCHLORIDE
  • VOLCIDOL as TRAMADOL HYDROCHLORIDE

  • (combination) HYCEPHEN as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) TARACET as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMACET as TRAMADOL HYDROCHLORIDE
  • (combination) ULTRACET as TRAMADOL HYDROCHLORIDE
  • (combination) ULTRAN as TRAMADOL HYDROCHLORIDE
  • (combination) WONTRAN as TRAMADOL HYDROCHLORIDE
  • (combination) ZIMACO as TRAMADOL HYDROCHLORIDE

Ireland (IE)

  • BY-MADOL as TRAMADOL HYDROCHLORIDE
  • TRADOL as TRAMADOL HYDROCHLORIDE
  • TRAMAKE as TRAMADOL HYDROCHLORIDE
  • XYMEL as TRAMADOL HYDROCHLORIDE
  • ZYDOL as TRAMADOL HYDROCHLORIDE

  • (combination) IXPRIM as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) XYMEL COMP as TRAMADOL HYDROCHLORIDE

Israel (IL)

  • TRAMADEX as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMARAZ as TRAMADOL HYDROCHLORIDE

  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

Japan (JP)

  • ONETRAM as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TWOTRAM as TRAMADOL HYDROCHLORIDE

  • (combination) TOARASET as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMCET as TRAMADOL HYDROCHLORIDE

Lithuania (LT)

  • MABRON as TRAMADOL HYDROCHLORIDE

  • (combination) CLOCINOL as TRAMADOL HYDROCHLORIDE
  • (combination) DORETA as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE

Malta (MT)

  • MABRON as TRAMADOL HYDROCHLORIDE
  • ZAMADOL as TRAMADOL HYDROCHLORIDE

  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE

Mexico (MX)

Netherlands (NL)

  • TRAMAGETIC as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE

  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

New Zealand (NZ)

  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMEDO as TRAMADOL HYDROCHLORIDE

Nigeria (NG)

Poland (PL)

  • ADAMON as TRAMADOL HYDROCHLORIDE
  • ORATRAM as TRAMADOL HYDROCHLORIDE
  • POLTRAM as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMALGIN as TRAMADOL HYDROCHLORIDE
  • TRAMUNDIN as TRAMADOL HYDROCHLORIDE

  • (combination) CURIDOL as TRAMADOL HYDROCHLORIDE
  • (combination) DELPARAN as TRAMADOL HYDROCHLORIDE
  • (combination) DORETA as TRAMADOL HYDROCHLORIDE
  • (combination) EXBOL as TRAMADOL HYDROCHLORIDE
  • (combination) PADOLTEN as TRAMADOL HYDROCHLORIDE
  • (combination) PALGOTAL as TRAMADOL HYDROCHLORIDE
  • (combination) PARCOTRAM as TRAMADOL HYDROCHLORIDE
  • (combination) POLTRAM COMBO as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) SYMTRAM as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMAPAR as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMIX as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMOFEN as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

Romania (RO)

  • MABRON as TRAMADOL HYDROCHLORIDE
  • TRAMACALM as TRAMADOL HYDROCHLORIDE
  • TRAMAG as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE

  • (combination) DORETA as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

Singapore (SG)

  • ACUGESIC as TRAMADOL HYDROCHLORIDE
  • DUROTRAM as TRAMADOL HYDROCHLORIDE
  • MABRON as TRAMADOL HYDROCHLORIDE
  • PENGESIC as TRAMADOL HYDROCHLORIDE
  • TRACIDOL as TRAMADOL HYDROCHLORIDE
  • TRADOL as TRAMADOL HYDROCHLORIDE
  • TRADONAL as TRAMADOL HYDROCHLORIDE

  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) ULTRACET as TRAMADOL HYDROCHLORIDE

South Africa (ZA)

  • DOLOTRAM as TRAMADOL HYDROCHLORIDE
  • DOLTREX as TRAMADOL HYDROCHLORIDE
  • DOMADOL as TRAMADOL HYDROCHLORIDE
  • LOPADEL as TRAMADOL HYDROCHLORIDE
  • MAKLODOL as TRAMADOL HYDROCHLORIDE
  • NOBLIGAN as TRAMADOL HYDROCHLORIDE
  • RAMTRID as TRAMADOL HYDROCHLORIDE
  • TRAMAHEXAL as TRAMADOL HYDROCHLORIDE
  • TRAMAL as TRAMADOL HYDROCHLORIDE
  • TRAMASPEN as TRAMADOL HYDROCHLORIDE
  • TRAMAZAC as TRAMADOL HYDROCHLORIDE
  • TRAMG ESIC as TRAMADOL HYDROCHLORIDE

  • (combination) CETADURE as TRAMADOL HYDROCHLORIDE
  • (combination) CETVIO as TRAMADOL HYDROCHLORIDE
  • (combination) DOLOTRAM PLUS as TRAMADOL HYDROCHLORIDE
  • (combination) DOLTREX CO as TRAMADOL HYDROCHLORIDE
  • (combination) DYTRACET as TRAMADOL HYDROCHLORIDE
  • (combination) LENIZAK as TRAMADOL HYDROCHLORIDE
  • (combination) MARTACET as TRAMADOL HYDROCHLORIDE
  • (combination) OZTRAK as TRAMADOL HYDROCHLORIDE
  • (combination) PAINOGESIC CO as TRAMADOL HYDROCHLORIDE
  • (combination) PATRAM as TRAMADOL HYDROCHLORIDE
  • (combination) QUELGEZ as TRAMADOL HYDROCHLORIDE
  • (combination) SKUDEXA as TRAMADOL HYDROCHLORIDE
  • (combination) TAMOLTRA as TRAMADOL HYDROCHLORIDE
  • (combination) TEMREZ as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMACET as TRAMADOL HYDROCHLORIDE
  • (combination) TRAMCO as TRAMADOL HYDROCHLORIDE
  • (combination) ULTRACET as TRAMADOL HYDROCHLORIDE

Spain (ES)

  • ADOLONTA as TRAMADOL HYDROCHLORIDE
  • GELOTRADOL as TRAMADOL HYDROCHLORIDE
  • TIONER as TRAMADOL HYDROCHLORIDE
  • TRADONAL as TRAMADOL HYDROCHLORIDE
  • ZYTRAM as TRAMADOL HYDROCHLORIDE

  • (combination) CAPTOR as TRAMADOL HYDROCHLORIDE
  • (combination) CLANDERON as TRAMADOL HYDROCHLORIDE
  • (combination) DILIBAN as TRAMADOL HYDROCHLORIDE
  • (combination) ENANPLUS as TRAMADOL HYDROCHLORIDE
  • (combination) PAXIFLAS as TRAMADOL HYDROCHLORIDE
  • (combination) PAZITAL as TRAMADOL HYDROCHLORIDE
  • (combination) PONTALSIC as TRAMADOL HYDROCHLORIDE
  • (combination) TRACIMOL as TRAMADOL HYDROCHLORIDE
  • (combination) ZALDIAR as TRAMADOL HYDROCHLORIDE

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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