POLARINE

This brand name is authorized in Singapore

Active ingredients

The drug POLARINE contains a combination of these active pharmaceutical ingredients (APIs):

1 Dexchlorpheniramine
UNII B10YD955QW - DEXCHLORPHENIRAMINE MALEATE

Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects.

Read about Dexchlorpheniramine
2 Pseudoephedrine
UNII 6V9V2RYJ8N - PSEUDOEPHEDRINE HYDROCHLORIDE

Pseudoephedrine is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. It has alpha and beta adrenergic activity and some stimulant effect on the central nervous system. The sympathomimetic effect of pseudoephedrine produces vasoconstriction which in turn relieves nasal congestion.

Read about Pseudoephedrine

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
R06AB52 Dexchlorpheniramine, combinations R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AB Substituted alkylamines
Discover more medicines within R06AB52

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: SG Health Sciences Authority Identifier(s): 03182P, 07612P

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