PRAMIGEL

This brand name is authorized in Mexico

Active ingredients

The drug PRAMIGEL contains a combination of these active pharmaceutical ingredients (APIs):

1 Aluminium hydroxide
UNII 5QB0T2IUN0 - ALUMINUM HYDROXIDE

Aluminium hydroxide is a slow-acting antacid. It is used to provide symptomatic relief in gastric hyperacidity. In addition, the antipeptic and demulcent activity of aluminium hydroxide helps to protect inflamed gastric mucosa against further irritation by gastric secretions.

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2 Magnesium hydroxide
UNII NBZ3QY004S - MAGNESIUM HYDROXIDE

Magnesium hydroxide is practically insoluble in water and solution is not effected until the hydroxide reacts with hydrochloric acid in the stomach to form magnesium chloride. Its neutralising action is almost equal to that of sodium bicarbonate. When the dose is in excess of that required to neutralise the acid the intragastric pH may reach pH 8 or 9. Acid rebound following magnesium hydroxide is clinically insignificant. Magnesium hydroxide has an indirect cathartic effect resulting from water retention in the intestinal lumen.

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3 Metoclopramide
UNII W1792A2RVD - METOCLOPRAMIDE HYDROCHLORIDE

The action of metoclopramide is closely associated with parasympathetic nervous control of the upper gastro-intestinal tract where it has the effect of encouraging normal peristaltic action. This provides for a fundamental approach to the control of those conditions where disturbed gastrointestinal motility is a common underlying factor.

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4 Simethicone
UNII 92RU3N3Y1O - DIMETHICONE

Simethicone is a chemically inert, non-systemic gastric defoaming agent that works by altering the elasticity of interfaces of mucus-embedded bubbles in the gastrointestinal tract. The gas bubbles are thus broken down or coalesced and in this form gas is more easily eliminated through eructation or passing flatus.

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Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: MX Comisiรณn Federal para la Protecciรณn contra Riesgos Sanitarios Identifier(s): 87632, 88438

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